Not for the first time, I wish MSM would stop stop cherry-picking and publishing click-bait headlines. We're living in times of rapid change and must either analyze the quoted study ourselves or, as is often the case, if the journal is behind a paywall we must rely on trusted analysts like Dr Jen. I also expect your advice and guidance will change with the evidence, as it should. I trust you and appreciate everything you do.
Side question. I notice that you said "people who experience more hot flashes are more likely to have changes in the brain that are associated with an increased risk of dementia." but at the same time that hormone therapy doesn't decrease dementia, even though it reduces hot flashes. That's an interesting contradiction. Do we have any explanation for that, or is it in the "needs further research" bucket with 10 million other women's health questions?
I have been on HRT for 3 years - 1st we tried patches, and then oral - but neither got my Estradiol levels to where I wasn't having hot flashes - so we finally went w injection. Both my reproductive endocrinologist AND my OBGYN (who do not practice together, but I share my test results) are happy w the values. I have PCOS - and had an ablation 7 years ago - because I was getting breakthrough full on periods every 2 weeks in my mid-40s. Come to find out I had a "textbook" fibroid - which was removed. Since my ablation I haven't had a period - which I did not complain one bit about. My OBGYN says the normal course of treatment on HRT is about 5 years. My reproductive endocrinologist says I can stay on it "as long as I want to - no limit". He's the one that put me on it. He said that he has had many patients who stopped after 5 years of treatment, felt like crap and went right back on it. I have my uterus - and take oral progesterone nightly. None of the studies I've read say anything about injectible estradiol ... what are your thoughts?
This is SO true. In addition,the reason why the risk of having dementia and/or Alzheimer is more in women than men is because of the low Estrogen level women have in menopause. Low estrogen level during menopause increases the level of pro-inflammatory markers (IL-1, TNF, and IL-6) in the brain which in turns cause brain inflammation leading to cognitive decline ( impairment).
This risk of getting Dementia in menopause is higher in women who did bilateral oophorectomy than those who did unilateral oophorectomy. Just because the ones who did bilateral oophorectomy have two of their ovaries removed.
Another condition is multiple sclerosis. This is 3 times more in women than men. Still due to the same reason of low estrogen level during menopause.
The solution is to do what Dr Gen wrote above
AND
To keep estrogen level up during menopause is to take HRT to prevent dementia or prevent it from getting worsen. According to a recent research.
Not for the first time, I wish MSM would stop stop cherry-picking and publishing click-bait headlines. We're living in times of rapid change and must either analyze the quoted study ourselves or, as is often the case, if the journal is behind a paywall we must rely on trusted analysts like Dr Jen. I also expect your advice and guidance will change with the evidence, as it should. I trust you and appreciate everything you do.
Thank you! I knew the minute I read about that study you would respond. I feel reassured!
Side question. I notice that you said "people who experience more hot flashes are more likely to have changes in the brain that are associated with an increased risk of dementia." but at the same time that hormone therapy doesn't decrease dementia, even though it reduces hot flashes. That's an interesting contradiction. Do we have any explanation for that, or is it in the "needs further research" bucket with 10 million other women's health questions?
I noticed correct hearing loss in the list of interventions....where can I learn more about this connection?
I have been on HRT for 3 years - 1st we tried patches, and then oral - but neither got my Estradiol levels to where I wasn't having hot flashes - so we finally went w injection. Both my reproductive endocrinologist AND my OBGYN (who do not practice together, but I share my test results) are happy w the values. I have PCOS - and had an ablation 7 years ago - because I was getting breakthrough full on periods every 2 weeks in my mid-40s. Come to find out I had a "textbook" fibroid - which was removed. Since my ablation I haven't had a period - which I did not complain one bit about. My OBGYN says the normal course of treatment on HRT is about 5 years. My reproductive endocrinologist says I can stay on it "as long as I want to - no limit". He's the one that put me on it. He said that he has had many patients who stopped after 5 years of treatment, felt like crap and went right back on it. I have my uterus - and take oral progesterone nightly. None of the studies I've read say anything about injectible estradiol ... what are your thoughts?
Hi Dr Jen. Pls can I follow you on twitter? To know when you post something new?
I’m @FaustaAai.
Many thanks
NB: The women who has Multiple sclerosis and take HRT suffer little or no symptoms compare to women who has Multiple sclerosis and not taking HRT.
😀
Kudos to Dr Gen.
This is SO true. In addition,the reason why the risk of having dementia and/or Alzheimer is more in women than men is because of the low Estrogen level women have in menopause. Low estrogen level during menopause increases the level of pro-inflammatory markers (IL-1, TNF, and IL-6) in the brain which in turns cause brain inflammation leading to cognitive decline ( impairment).
This risk of getting Dementia in menopause is higher in women who did bilateral oophorectomy than those who did unilateral oophorectomy. Just because the ones who did bilateral oophorectomy have two of their ovaries removed.
Another condition is multiple sclerosis. This is 3 times more in women than men. Still due to the same reason of low estrogen level during menopause.
The solution is to do what Dr Gen wrote above
AND
To keep estrogen level up during menopause is to take HRT to prevent dementia or prevent it from getting worsen. According to a recent research.
Well done Dr Gen. 🫶
No, dr Gen said sth completely different. No one sould take estrogen to prevent dementia. Are you a troll?