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Tracy Luo's avatar

Thanks for another great post 🥰

“Premature ovarian failure is awfully pejorative; after all, no one ever tells men that their inability to get or maintain an erection as they age is senile penile failure.” 😂

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Dr. Jen Gunter's avatar

I mean...right?

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Kirsten's avatar

I wasn’t diagnosed with POI though I started having fewer than 3 periods/year at age 39. My doctor kept saying “you’re too young for this,” as if that made it not happen. She’d prescribe oral contraceptives that would make me bleed for weeks and since the contraception wasn’t needed I opted not to continue. Irregular periods were better than constant ones. Fast forward to finding you and reading about POI and now I’m on prempro and wondering if that’s sufficient (am now 45). I also have rheumatoid arthritis (diagnosed at 20), so POI should not be surprising yet my rheumatologist and gynecologist both seemed dumbfounded by my experience. Thank you for your wonderful information and willingness to support women/people with uteruses being informed about their health.

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Ashley Cole's avatar

Thank you so much for this great article in what seems to be an understudied space! I’m confused about the diagnostic criteria for early menopause/POI. If FSH and estradiol levels fluctuate wildly during the menopause transition, are elevated FSH levels really needed to warrant starting HRT for women with signs/symptoms of menopausal who are age<45 (esp in the presence of family history of early menopause and/or once other causes have been ruled out)? Given that the benefit/risk profile of HRT seems very favorable in this population, and hormone levels seem to be not very informative for menopausal status generally, it seems somewhat contradictory to base treatment decisions on FSH for early menopause/POI (particularly since women in this age range commonly take much higher doses of estrogen as contraception). Am I misunderstanding?

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KC Cahill's avatar

What can a woman do if she didn’t start HRT at the time, will MRT help play catch-up to lower overall risks??

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Jenn's avatar

I did a double take when I read that mumps could cause POI. I am of the pre-MMR vaccination generation. Mumps was one of “the usual childhood diseases”.

Did the statistics on the rate of POI drastically change when the first group of girls who had been vaccinated against measles go through puberty?

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Megan's avatar

Thank you so much for covering this! I haven’t met anyone who knows what POI is when I tell them. Just curious - Does the research find a difference in dementia/cardiovascular/bone risk between those who have early onset POI (in their 20s) vs later onset (late 30s)? I ask because I had my last child at 38 years old and was diagnosed with POI at 39 years old. I’ve tried HRT and have really struggled with acne. I’m not taking HRT now, yet whenever I hear “dementia”, my nerves kick in.

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Kamini R's avatar

I was diagnosed with POI going thru IVF in my mid 30s- this was such an informative piece for me! I want to help find a good Gyn for my niece who can help her thru testing- she just moved to Houston. Any suggestions of resources to find specialistswho are well versed in POI?

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