Ugh. A friend of mine uses these to “fix her ph” after her period each month. She is in peri menopause and is probably damaging her vagina. I’m sending her this article.
This study does not support her product at all. It is not a clinical trial but rather an explanation of what the microbiome looks like. It is predatory to use that article to sell a product.
New instagram post I saw today by Dr Vonda Wright citing a study for new research in l. Rhamnosus and rheuteri (hope I spelt right) and product called Nova MD. Can you tell us about the study and her claims? If you already have elsewhere please just post link here. Thanks
It looks like NovaMD is her specific line of supplements. The site says "NovaMD was formulated by Dr. Vonda Wright." No probiotic has been rigorously clinically tested and is also commercially available which offers any proven benefit for vaginal health. Dr. Wright is an orthopedic surgeon, so I am not clear about her expertise here. Doctors can make a fuck ton, and I mean a fuck ton, selling these white-label supplements.
So a product like repHresh is worthless? Sorry, you may have addressed this elsewhere already. If so please put link here. I have a hard time searching on the Substack app or on my phone.
That’s insane what people use boric acid for. I had never heard of that! It was used in early photographic processes (think 1840-50s). I do some alternative photographic processes that use boric acid (borax).
That’s insane what people use boric acid for. I had never heard of that! It was used in early photographic processes (think 1840-50s). I do some alternative photographic processes that use boric acid (borax).
Jen, I have animal and human data showing high efficacy, approaching 100% and all women have loved the immediate symptom relief. From an FDA standpoint--they referred us for 'Breakthrough Designation"--11 of the 30 women were under trial supervision--one IRB approved. Device studies only require one and the sample size is usually less than 100. Safety has also been conducted. It's safer than a tampon and menstrual cup. Every woman who used the device gave it rave reviews. One even said she was ready to cry and vowed to help me get it on the market. If you want, I can send the White Papers/slide deck because the way it works is via 4 mechanisms vs drugs that have one. We have proven 2 of the 4 mechanisms in the human and mouse model, and have extensive microbiologic research in support for the third and fourth mechanisms. The reason it works in both conditions is the device preserves the lactobacillus that stabilizes the pH and breaks up biofilms. I know it seems amazing and too good to be true, but I experienced the cure myself. I have a lot of OB/GYNs excited to have this available, especially for recurrent sufferers. We are getting ready to start the official clinical trial. I'll send the data if you want. This device is for 30-minute use and is disposable. Symptom relief is within minutes.
We really don't understand the pathogenesis of recurrent yeast of BV. There are many fungal and bacterial virulence factors involved, as well as a variety of host factors. The idea that a single therapy can cure both within minutes is very bold, and bold claims require bold evidence, not anecdotes. Your personal experience is an anecdote, and as the CEO, it is also biased. I await your multi-center sham-controlled clinical trials.
Yes, I will provide those results when it is finished. I already have eleven women who were confirmed to have VVC and three of them had VVC and BV by MDs (not me) under trial supervision at different locations and different years who all were cured of both conditions. And 25 more who were diagnosed by MDs and given the device for use. I appreciate your skepticism, but you should know that the technology worked in the mouse model by the PhD experts who also tested the drugs. The drugs failed the mouse model--and we reached p values of 0.0002 and 0.0033 for reduction in hyphae and PMNs. That alone should make you less skeptical. Also, lactobacillus is metabolically active in the cold as it is used in the ice cream and yogurt industries to acidify, preserve, and flavor the food because of that ability to produce lactic acid in cold environments. Also, the device breaks up biofilms via three mechanisms via farnesol, sheering, and pH normalization. These are the two final reasons to explain the high effectiveness. The first two mechanisms were confirmed in both human and mice to reduce inflammation from the PMNs, and reverse morphology due to farnesol release by the Candida and in some cases kill it, which was confirmed mycologically in 2 cases. The pH elevation/biofilm are crucial virulence factors that are mitigated by the device. As you know pH elevation triggers VVC and some MDs think BV may be a requirement to do this--but it awaits further study. With regard to device studies, the participant serves as her own control and that is acceptable for approval by the FDA. Once approved, we will seek a comparator drug arm even though we have 100s if not 1000s of studies that calculated their effectiveness, which is waning due to drug resistance. Our device could substantially decrease the overuse of partially effective antifungal drugs. In any case, those studies will be more important to make superiority claims and prove faster symptom relief, which is huge. If you'd like to read my research, please email me at kim@coologics.com and I will send you the material. Thanks for asking me to explain. When you read the material and look at the data, you will realize why I am taking this BOLD journey and would love you to consider being part of my Medical/Scientific Advisory Board. I have 6 MDs/PhDs on board already, but I am seeking more females. If you would like me to send you some devices for use, I would be happy to. Thanks for your feedback. Kim
Hi, I totally agree with Dr. Jen!!! The good news is that Coologics is coming out with Vlisse--a drug-free faster and more effective treatment for both bacterial and yeast infections of the vagina. And, one that stops symptoms immediately. It's a 30 minute vaginal device. Be on the LOOKOUT. https://coologics.com
I will absolutely not be recommending this device until there are robust clinical trials. Also, the idea that BV and yeast can be treated with the same technology is a fantastical claim, and fantastical claims require fantastical evidence. And 30 people in an industry-funded study (which is what appears on the website) is not fantastical evidence.
Did you really assume people reading your comment here would know that you are the CEO? You should have been fully transparent and indicated in your first comment that you are the CEO and thus have a significant conflict of interest.
I’ve been suffering miserable symptoms for months, and yeast culture came back positive for Sacch. cerivisiae. Regular yeast medication did not help. Have tried two weeks boric acid to great relief. However a week after stopping symptoms are back. No one can advise me on what to do and I know boric acid isn’t a sustainable therapy.
I know you have mentioned some clinical trials on probiotics for BV in the past. Is there a probiotic product you would recommend people try?
Ugh. A friend of mine uses these to “fix her ph” after her period each month. She is in peri menopause and is probably damaging her vagina. I’m sending her this article.
https://pubmed.ncbi.nlm.nih.gov/24080849/ Thank you!
This study does not support her product at all. It is not a clinical trial but rather an explanation of what the microbiome looks like. It is predatory to use that article to sell a product.
She cites a research article so I was hoping someone with more experience in reviewing research (you) could review it.
I don't follow her, and the study is not listed on the website. So if you could share it here I can take a look at it.
New instagram post I saw today by Dr Vonda Wright citing a study for new research in l. Rhamnosus and rheuteri (hope I spelt right) and product called Nova MD. Can you tell us about the study and her claims? If you already have elsewhere please just post link here. Thanks
It looks like NovaMD is her specific line of supplements. The site says "NovaMD was formulated by Dr. Vonda Wright." No probiotic has been rigorously clinically tested and is also commercially available which offers any proven benefit for vaginal health. Dr. Wright is an orthopedic surgeon, so I am not clear about her expertise here. Doctors can make a fuck ton, and I mean a fuck ton, selling these white-label supplements.
Can you comment on using lactobacilli in the vagina to replenish the pH?
There is no lactobacilli that can do this
So a product like repHresh is worthless? Sorry, you may have addressed this elsewhere already. If so please put link here. I have a hard time searching on the Substack app or on my phone.
That’s insane what people use boric acid for. I had never heard of that! It was used in early photographic processes (think 1840-50s). I do some alternative photographic processes that use boric acid (borax).
That’s insane what people use boric acid for. I had never heard of that! It was used in early photographic processes (think 1840-50s). I do some alternative photographic processes that use boric acid (borax).
Jen, I have animal and human data showing high efficacy, approaching 100% and all women have loved the immediate symptom relief. From an FDA standpoint--they referred us for 'Breakthrough Designation"--11 of the 30 women were under trial supervision--one IRB approved. Device studies only require one and the sample size is usually less than 100. Safety has also been conducted. It's safer than a tampon and menstrual cup. Every woman who used the device gave it rave reviews. One even said she was ready to cry and vowed to help me get it on the market. If you want, I can send the White Papers/slide deck because the way it works is via 4 mechanisms vs drugs that have one. We have proven 2 of the 4 mechanisms in the human and mouse model, and have extensive microbiologic research in support for the third and fourth mechanisms. The reason it works in both conditions is the device preserves the lactobacillus that stabilizes the pH and breaks up biofilms. I know it seems amazing and too good to be true, but I experienced the cure myself. I have a lot of OB/GYNs excited to have this available, especially for recurrent sufferers. We are getting ready to start the official clinical trial. I'll send the data if you want. This device is for 30-minute use and is disposable. Symptom relief is within minutes.
We really don't understand the pathogenesis of recurrent yeast of BV. There are many fungal and bacterial virulence factors involved, as well as a variety of host factors. The idea that a single therapy can cure both within minutes is very bold, and bold claims require bold evidence, not anecdotes. Your personal experience is an anecdote, and as the CEO, it is also biased. I await your multi-center sham-controlled clinical trials.
Yes, I will provide those results when it is finished. I already have eleven women who were confirmed to have VVC and three of them had VVC and BV by MDs (not me) under trial supervision at different locations and different years who all were cured of both conditions. And 25 more who were diagnosed by MDs and given the device for use. I appreciate your skepticism, but you should know that the technology worked in the mouse model by the PhD experts who also tested the drugs. The drugs failed the mouse model--and we reached p values of 0.0002 and 0.0033 for reduction in hyphae and PMNs. That alone should make you less skeptical. Also, lactobacillus is metabolically active in the cold as it is used in the ice cream and yogurt industries to acidify, preserve, and flavor the food because of that ability to produce lactic acid in cold environments. Also, the device breaks up biofilms via three mechanisms via farnesol, sheering, and pH normalization. These are the two final reasons to explain the high effectiveness. The first two mechanisms were confirmed in both human and mice to reduce inflammation from the PMNs, and reverse morphology due to farnesol release by the Candida and in some cases kill it, which was confirmed mycologically in 2 cases. The pH elevation/biofilm are crucial virulence factors that are mitigated by the device. As you know pH elevation triggers VVC and some MDs think BV may be a requirement to do this--but it awaits further study. With regard to device studies, the participant serves as her own control and that is acceptable for approval by the FDA. Once approved, we will seek a comparator drug arm even though we have 100s if not 1000s of studies that calculated their effectiveness, which is waning due to drug resistance. Our device could substantially decrease the overuse of partially effective antifungal drugs. In any case, those studies will be more important to make superiority claims and prove faster symptom relief, which is huge. If you'd like to read my research, please email me at kim@coologics.com and I will send you the material. Thanks for asking me to explain. When you read the material and look at the data, you will realize why I am taking this BOLD journey and would love you to consider being part of my Medical/Scientific Advisory Board. I have 6 MDs/PhDs on board already, but I am seeking more females. If you would like me to send you some devices for use, I would be happy to. Thanks for your feedback. Kim
Hi, I totally agree with Dr. Jen!!! The good news is that Coologics is coming out with Vlisse--a drug-free faster and more effective treatment for both bacterial and yeast infections of the vagina. And, one that stops symptoms immediately. It's a 30 minute vaginal device. Be on the LOOKOUT. https://coologics.com
I will absolutely not be recommending this device until there are robust clinical trials. Also, the idea that BV and yeast can be treated with the same technology is a fantastical claim, and fantastical claims require fantastical evidence. And 30 people in an industry-funded study (which is what appears on the website) is not fantastical evidence.
Also, you are the founder and CEO of this company, so you should be disclosing that in your comment.
Ok, since it's on the website, I assumed people knew that I was the inventor, founder, CEO, but it's official now. Thanks.
Did you really assume people reading your comment here would know that you are the CEO? You should have been fully transparent and indicated in your first comment that you are the CEO and thus have a significant conflict of interest.
I have struggled with BV a few times in my life.
Flagyl didn’t help. Weirdly, the boric acid did. Maybe this was just coincidental, but I was impressed.
I’ve been suffering miserable symptoms for months, and yeast culture came back positive for Sacch. cerivisiae. Regular yeast medication did not help. Have tried two weeks boric acid to great relief. However a week after stopping symptoms are back. No one can advise me on what to do and I know boric acid isn’t a sustainable therapy.