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Just an added note on placebo response: When Ortho Pharm. tested Ortho Tri-Cyclen to get an indication for improving acne, it performed better than placebo, but about 36% (if my memory isn't too faulty) on the placebo also showed improvement.

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Thanks for the deep dive on this, and the graphics are charmingly good. It will help me to be conversant about this with my people in primary care, and perhaps prescribe at times... but I think I will still recommend “talking to your Gyn” first. I do wish the hot flashes went to zero for that price, and very odd how the inflation adjusted cost parallels Viagra. I think brexafemme was introduced at $700/course, and the GLP 1 drugs like semaglutide run 800-1000/ month, so it’s kind of the going rate these days in America?

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